Cancer Biology
ISSN: 2150-1041 (print); ISSN: 2150-105X (online),
Quarterly
Volume 03 / Issue 02, Cumulated No. 10, June 25, 2013
Cover, Introduction, Contents
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CONTENTS
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No.
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Titles / Authors
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Text
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No.
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1
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Molecular
study
of
the
retinoblastoma
in
western
Algerian
population.
Research of
gene Rb
mutations
at
the
constitutional
level.
Lotfi Louhibi1, 2, Amina Mama Boubekeur2,
Khadidja Mahmoudi3, Rym Khadidja Abderrahmane2,
Fatima Zohra Nehili4, Abdellah Boudjema2,
Meriem Aberkane5, Nadhira Saidi-Mehtar2.
1 –
Faculty
of Science,
department
of Biotechnology, University of
Oran Es-
Senia,
Oran, Algeria
2 -
Faculty
of Science,
department
of
Applied
Molecular
Genetics,
University of Science
and Technology of Oran,
Mohamed Boudiaf, Oran, Algeria
3 -
Pediatric
Ophtalmology
Service «
pediatric
Hospital
EHS
of Canastel
» Oran, Algeria
4 -
Ophtalmology
Service, Ophtalmology
Clinic «
Front de
mer
» CHU
Oran, Algeria
5 -
Faculty
of
Medecine,
University of
Oran Es-sénia,
Oran, Algeria.
Lotfi Louhibi: Email adress:
louhibi@yahoo.com.
Phone : +213665003191, ful postal address:
University
of Science and
Technology Mohamed Boudiaf, El mnaouar 1505 USTO-MB
31000 Oran, Algeria.
Background:
Retinoblastoma
is a
malignant
intraocular
tumour
which
generally
reaches the
child
with a
frequency
from
1/15000
to 1/20000.
Antioncogene Rb
changes (chromosome 13q14.2),
are
at
the origin
of this
cancer. Two
allele’s mutations of
this gene
are required
for
retinoblastoma
development.
The aim
of
this
study
is research
and identification
of
mutations able
to affect the gene Rb
at
the constitutional level. Methods:
Study
concern
61 patients.
The twenty-seven
exons and promoter
of Rb
gene
were
amplified
by
PCR,
with
15
exons studied
by DGGE
(Denaturing Gel Gradient
Electrophoresis)
and
12
by
SSCP
(Single Strand
Conformation
Polymorphism).
These techniques
allow
selecting
cases
for sequencing.
Results: Sequencing
results
gave nineteen
different
variations bases,
including seven
exonic changes: five nonsens
mutations located in
exons
1,7,8,18 and
23 and two
misense mutations in
exons
19 and
20. These changes
remain
minority
compared
to the twelve
intronic changes
whose
possible
implication
remains to be
elucidated.
Polymorphisms found
in
exons 2,3,4,11
and 17
were
already described
in the literature.
Conclusion:
Neomutations
detection is
important because it allows both
the early treatment
of children with the
mutated gene that screening
asymptomatic carriers
at risk of transmitting the disease
to their offspring.
[Lotfi Louhibi, Amina Mama Boubekeur, Khadidja Mahmoudi, Rym
Khadidja Abderrahmane, Fatima Zohra Nehili, Abdellah Boudjema,
Meriem Aberkane, Nadhira Saidi-Mehtar.
Molecular
study
of
the
retinoblastoma
in
western
Algerian
population.
Research of
gene Rb
mutations
at
the
constitutional
level.
Cancer Biology
2013;3(2):1-7]. (ISSN:
2150-1041).
http://www.cancerbio.net.
1
doi:10.7537/marscbj030213.01
Keywords:
Molecular;
retinoblastoma;
western
Algerian;
population;
Research; gene
Rb; mutations;
constitutional
level. |
Full
Text |
1
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2
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Thyoid Cancer
Mark H
Smith
Queens,
New York 11418, USA
mark20082009@gmail.com
Abstract:
Cancer is the cells that grow
out of control. Cancer cells can also invade other tissues.
Growing out of control and invading other tissues are what makes
a cell a cancer cell. Involved in more
than 100 diseases, the cancer can cause serious illness and
death.Normally, the cells become cancer cells because of DNA
damage. This material is a literature collection of the
researches on the thyoid cancer.
[Smith MH.
Thyoid Cancer.
Cancer Biology
2013;3(2):8-92]. (ISSN:
2150-1041).
http://www.cancerbio.net. 2
doi:10.7537/marscbj030213.02
Keywords:
cancer; thyoid; biology; life; disease; research; literature
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Full
Text |
2
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3
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Cancer and
Tobacco Literature
Mark H
Smith
Queens,
New York 11418, USA
mark20082009@gmail.com
Abstract:
Cancer is the cells that grow
out of control. Cancer cells can also invade other tissues.
Growing out of control and invading other tissues are what makes
a cell a cancer cell. Involved in more
than 100 diseases, the cancer can cause serious illness and
death. Normally, the cells become cancer cells because of DNA
damage. This material is a literature collection of the
researches on the cancer and tobacco.
[Smith MH.
Cancer and Tobacco.
Cancer Biology
2013;3(2):93-119]. (ISSN:
2150-1041).
http://www.cancerbio.net. 3
doi:10.7537/marscbj030213.03
Keywords:
cancer; biology; life; disease; research; literature; tobacco |
Full
Text |
3
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4
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Cancer Symptom
Mark H
Smith
Queens,
New York 11418, USA
mark20082009@gmail.com
Abstract:
Cancer is the cells that grow
out of control. Cancer cells can also invade other tissues.
Growing out of control and invading other tissues are what makes
a cell a cancer cell. Involved in more
than 100 diseases, cancers can cause serious illness and death.
Normally, the cells become cancer cells because of DNA damage.
This material is a literature collection of the researches on
the cancer symptom.
[Smith MH.
Cancer Symptom.
Cancer Biology
2013;3(2):120-203]. (ISSN:
2150-1041).
http://www.cancerbio.net. 4
doi:10.7537/marscbj030213.04
Keywords:
cancer; biology; life; disease;
research; literature; symptom |
Full
Text |
4
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5
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Cancer
Vaccination
Mark H
Smith
Queens,
New York 11418, USA
mark20082009@gmail.com
Abstract:
Cancer is the cells that grow
out of control. Cancer cells can also invade other tissues.
Growing out of control and invading other tissues are what makes
a cell a cancer cell. Involved in more
than 100 diseases, cancers can cause serious illness and death.
Normally, the cells become cancer cells because of DNA damage.
This material is a literature collection of the researches on
the cancer vaccination.
[Smith MH.
Cancer
Vaccination.
Cancer Biology
2013;3(2):204-267]. (ISSN:
2150-1041).
http://www.cancerbio.net. 5
doi:10.7537/marscbj030213.05
Keywords:
cancer; biology; life; disease; research; literature;
vaccination |
Full
Text |
5
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6
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Breast
Cancer
Mark H
Smith
Queens,
New York 11418, USA
mark20082009@gmail.com
Abstract:
Cancer is the cells that grow
out of control. Cancer cells can also invade other tissues.
Growing out of control and invading other tissues are what makes
a cell a cancer cell. Involved in more
than 100 diseases, cancers can cause serious illness and death.
Normally, the cells become cancer cells because of DNA damage.
This material is a literature collection of the researches on
the breast cancer.
[Smith MH.
Breast
Cancer. Cancer
Biology
2013;3(2):268-295]. (ISSN:
2150-1041).
http://www.cancerbio.net. 6
doi:10.7537/marscbj030213.06
Keywords:
cancer; biology; life; disease; research; literature; breast |
Full
Text |
6
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7
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Brain Cancer
Mark H
Smith
Queens,
New York 11418, USA
mark20082009@gmail.com
Abstract:
Cancer is the cells that grow
out of control. Cancer cells can also invade other tissues.
Growing out of control and invading other tissues are what makes
a cell a cancer cell. Involved in more
than 100 diseases, cancers can cause serious illness and death.
Normally, the cells become cancer cells because of DNA damage.
This material is a literature collection of the researches on
the brain cancer.
[Smith MH. Brain
Cancer.
Cancer Biology
2013;3(2):296-311]. (ISSN:
2150-1041).
http://www.cancerbio.net. 7
doi:10.7537/marscbj030213.07
Keywords:
cancer; biology; life; disease; research; literature; brain
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Full
Text |
7
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from 5/2/2013.
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